Midtown is a neighborhood in Harrisburg, Pennsylvania. Its zip code is 17102. The Midtown neighborhood is delineated by Forster Street to the south, Maclay Street to the north, 7th Street to the east, and the Susquehanna River to the west. Former Harrisburg Mayor William K. Verbeke is the namesake for Verbeke Street (formerly Broad Street) and first bought and developed the area. Midtown is home to the Pennsylvania Governor's Residence (at its boundary with Uptown) and the Broad Street Market, the oldest continually operated street market in the country.

Midtown became named as such following World War II as state government construction expanded further north from the Capitol District. By 1977 the Midtown Square Action Council was established, and starting with the 1980s revitalization began and has continued since.

The section of Midtown from Reily to Kelker Streets and 2nd to 3rd Streets is known as Engleton. Its Queen Anne style homes were built in the 1890s by Benjamin Engle. The Old Uptown, Old Midtown, and Old Fox Ridge historic districts listed on the National Register of Historic Places are all contained within the Midtown neighborhood.

Olde Uptown is a neighborhood of large homes built in the early 1900s between Kelker and Maclay streets. The area, crime ridden for many years, is currently being aggressively renovated and rehabbed. Much of this neighborhood lies within the Old Uptown Historic District.